Cell- and animal-based models of bone formation reveal novel mechanisms involved in the cartilage-to-bone phenotype ...

A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering potential therapeutic applications for osteoporosis. NELL2 promotes ...

A newly discovered receptor switch that boosts bone growth could transform how we treat osteoporosis, by stimulating the body’s own bone-building machinery using a targeted drug and even mechanical ...

Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation, a new study has found.

A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering potential therapeutic applications for osteoporosis. NELL2 promotes ...

Osteoporosis is a common disorder in which bones lose density and become more fragile. Over time, that raises the risk of ...

As flare-ups often precede the formation of new lesions, we are encouraged that this investigational drug may help prevent the progression of FOP. "The loss of mobility created by the abnormal bone ...

Obesity is widely known for increasing the risk of diabetes and cardiovascular disease, but its damaging effects on the skeleton are often overlooked. Excess body fat can disrupt bone metabolism, ...

A new small molecule could treat and prevent excess bone formation. Fibrodysplasia ossificans progressiva (FOP) is an extremely rare disease estimated to affect about one in 2 million people worldwide ...