It's been long established that our working memory, which allows us to temporarily hold and use information, such as remembering a phone number or a shopping list, is largely driven by the brain's ...

Schematic model showing how memory is consolidated in the prefrontal cortex and how circuitry through the amygdala shifts as hippocampal engram cells become silent and cortical engrams become active.

A study published in Nature on August 6, 2025, found that lithium is the only metal significantly depleted in the prefrontal cortex of people with mild cognitive impairment and Alzheimer’s disease, ...